Genome MuSIC 설치 및 사용방법

URL : http://gmt.genome.wustl.edu/genome-music/current/

$ wget -q -O - https://apt.genome.wustl.edu/ubuntu/files/install.sh | sudo bash

$ sudo genome install genome-music

$ genome music -h

Sub-commands for genome music:

 bmr                   ...  Calculate gene coverages and background mutation rates.     

 clinical-correlation       Correlate phenotypic traits against mutated genes, or against individual variants                                

 cosmic-omim                Compare the amino acid changes of supplied mutations to COSMIC and OMIM databases.                                 

 mutation-relation          Identify relationships of mutation concurrency or mutual exclusivity in genes across cases.                         

 path-scan                  Find signifcantly mutated pathways in a cohort given a list of somatic mutations.                                      

 pfam                       Add Pfam annotation to a MAF file                           

 play                       Run the full suite of MuSiC tools sequentially.             

 proximity                  Perform a proximity analysis on a list of mutations.        

 smg                        Identify significantly mutated genes.                       

 survival                   Create survival plots and P-values for clinical and mutational phenotypes.